16 December 2025

What Is the Best Injection for Knee Pain? PRP, Gel, or Steroids?

Confused by the options? We compare PRP, Hyaluronic Acid (Gel), and Steroids to help you decide which knee injection is best for your arthritis.

What Is the Best Injection for Knee Pain? PRP, Gel, or Steroids?

There is no single "magic bullet" for everyone. The "best" injection depends on your specific condition.

Here is a simple guide to matching the shot to the patient.


1. The "Emergency Firefighter": Corticosteroid

  • Best For: Acute, severe pain flare-ups. Swollen, hot knees.
  • Scenario: "My knee suddenly swelled up and I can't walk," or "I have a holiday next week."
  • Verdict: Great for quick, short-term relief. Not a long-term cure.

2. The "Lubricator": Hyaluronic Acid (Gel)

  • Best For: Moderate arthritis (Stage 2-3) with stiffness and grinding.
  • Scenario: "My knee aches constantly and feels creaky."
  • Verdict: Great for improving mechanics and reducing dull ache.

3. The "Healer": Platelet-Rich Plasma (PRP)

  • Best For: Early to Moderate arthritis (Stage 1-3) in active people.
  • Scenario: "I want to delay surgery and preserve my knee health naturally."
  • Verdict: The best biological option for long-term health and symptom modification.

The Winner?

Scientific studies increasingly favor PRP for long-term outcomes, but Steroids win for instant gratification.

Often, a combination approach works best. (e.g., quiet the inflammation with a steroid, then follow up with PRP a month later).


Takeaway

Don't guess. Let your X-rays and symptoms decide.

Dr. Abhijit Kale will evaluate your knee stage and recommend the injection that gives you the most mileage.

Dr. Abhijit Kale

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