16 December 2025

PRP vs. Steroid Injection: Which Is Better for Knee Pain?

Choosing between PRP and Cortisone shots? We compare the pros and cons of steroid injections vs. PRP therapy for knee arthritis relief.

PRP vs. Steroid Injection: Which Is Better for Knee Pain?

When pills and physiotherapy aren't enough, injections are the next step. But which one?

The two most common options are Corticosteroids (Steroids) and Platelet-Rich Plasma (PRP). They work in completely different ways.

Here is a simple comparison to help you decide.


1. Corticosteroids (The "Fire Extinguisher")

Steroids are powerful anti-inflammatories.

  • How they work: They shut down inflammation immediately.
  • Speed: Very fast. Pain relief often starts within 24-48 hours.
  • Duration: Short-term. Relief usually lasts 2 to 3 months.
  • The Downside: Frequent steroid injections can actually weaken cartilage over time. They mask the pain but don't heal the tissue.
  • Cost: Inexpensive and covered by most insurance.

Best for: Severe, acute flare-ups where you need quick relief to get moving again.


2. PRP (The "Gardener")

PRP uses your own blood's growth factors to stimulate healing.

  • How they work: They release biological signals to repair tissue and reduce inflammation naturally.
  • Speed: Slow. You might not feel relief for 3-4 weeks.
  • Duration: Long-term. Relief can last 6 to 12 months or more.
  • The Upside: No risk of cartilage damage. It may actually slow down arthritis progression.
  • Cost: More expensive and often not covered by insurance.

Best for: Long-term management of mild to moderate arthritis in active patients.


Summary Comparison

FeatureSteroidPRP
ActionStop InflammationPromote Healing
OnsetFast (Days)Slow (Weeks)
DurationShort (Months)Long (Year+)
Cartilage HealthCan be harmful if overusedPotentially beneficial
SafetyGoodExcellent (Natural)

Takeaway

  • Need to walk at a wedding next week? Steroid might be the answer.
  • Want to preserve your knee for the next 5 years? PRP is the better investment.

Discuss your goals with Dr. Abhijit Kale to choose the right tool for the job.

Dr. Abhijit Kale

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